Friday, November 2, 2007

Researchers at Case Western University in Cleveland, Ohio have announced the creation of transgenic mice with substantially improved athletic endurance, which live and breed longer and are more aggressive than genetically unmodified siblings, and are leaner despite consuming 60% more food. The mice have been dubbed “mighty mice” or “supermice” by the popular press and have been compared to cyclist Lance Armstrong.

The changes were created by adding an extra copy of a single gene, PEPCK-C. This gene is already present in the mouse genome, but the modified gene is designed to be strongly active (transcribed) in skeletal muscle. (The natural copy of the gene, most active in the liver, continues to function normally). The gene mediates a crucial rate controlling step of gluconeogenesis and glyceroneogenesis, and its activity helps to allow energy production by the mitochondrial citric acid cycle. In the transgenics, more energy is available to muscle through the burning of fatty acids, with much less production of lactate (a chemical that leads to sore muscles when one exercises). This is not as major a change to the mouse genome as it might seem to the layperson. The PEPCK-C gene is already present in the mouse and a variety of natural mutations could likely cause similar results. The study appears today in the Journal of Biological Chemistry in a paper with lead author Parvin Hakimi from the laboratory of Richard W. Hanson.

The altered mice can run at 20 meters per minute (0.75 miles per hour or 1.2 kilometers per hour) for up to six kilometers (nearly four miles) without stopping. The average treadmill time for strenuous exercise on a 25-degree incline is 31.9 minutes, well in excess of the 19 minute average of unmodified mice. Females can breed at two and a half years of age, whereas most female mice cannot breed after the first year.

A colony of 500 mice has been bred, starting from six independent germline transformations (“founder” mice). The level of PEPCK-C in muscle is 9 units per gram of muscle as opposed to only 0.08 in normal mice. Levels of triglycerides and the number of mitochondria are also increased.

Hanson said that he did not expect that the results would be applicable to humans due to both practical and ethical considerations in addition to the fact that the genes might not function the same way in humans.

This is not the first time that the press has dubbed a genetically modified mouse a “mighty mouse”. Earlier scientists at John Hopkins University announced that they had made mice with massively increased muscle mass that were larger and stronger than their normal cousins. These alterations increased strength rather than endurance through the genetic modification of myostatin and follistatin, or by injection of a soluble form of ACVR2B to block myostatin activity in normal mice.

Saturday, April 3, 2010

Nearly two feet of the rail route in Kashmir, India was blown up by militants near the Pulwama district, affecting train services from north to south Kashmir. The blast came a few days after militants fought with the Indian army in the area, thereby killing fourteen people.

“There were no casualties, as no trains were running when the militants set off a powerful bomb on the railway track,” said Aijaz Ahmad, a local police official. He added that train services have been temporarily suspended.

According to police, the attackers detonated an Improvised Explosive Device (IED) near Galbug at about 10 PM local time (4:30 PM UTC), Thursday night. Two feet of the rail track on the Qazigund-Baramulla area was damaged. This track was developed two years ago, police sources stated. The attack came just before senior officers were supposed to inspect ongoing works in the Kashmiri railways.

The track was repaired on Friday morning and train services resumed in the region. Kamal Saine, Deputy Inspector General of Police, south Kashmir, told the Press Trust of India agency that the damage to the track was not significant and it took a short time to mend it.

Tuesday, September 24, 2019

Today at 10:30 BST (0930 UTC), the Supreme Court of the United Kingdom issued a ruling on the prorogation — a procedural suspension — of the Parliament of the United Kingdom until October 14. The court found that it could rule on the prorogation, and found the prorogation to be unlawful. The Supreme Court is the final court of appeal on all civil matters in the United Kingdom, as well as criminal matters in parts of the United Kingdom. The Supreme Court is led by President Brenda Hale.

The summary of the decision read in part: “This Court has already concluded that the Prime Minister’s advice to Her Majesty was unlawful, void and of no effect. This means that the Order in Council to which it led was also unlawful, void and of no effect and should be quashed. This means that when the Royal Commissioners walked into the House of Lords it was as if they walked in with a blank sheet of paper. The prorogation was also void and of no effect. Parliament has not been prorogued. This is the unanimous judgment of all 11 Justices.”

Queen Elizabeth II suspended parliament at the behest of Boris Johnson, the current prime minister, on September 10. He is widely suspected of asking for prorogation to prevent legislative interference in his efforts to complete the withdrawal of the United Kingdom from the European Union (EU), known as Brexit for British exit. Following that reasoning, the Court of Session in Scotland ruled on September 11 the prorogation was unlawful. The Supreme Court ruled on the appeal of that decision by Johnson’s government.

The High Court of England and Wales also ruled on the same day as the Scottish court, finding that the prorogation of Parliament was not a matter for the courts: “In our view, the decision of the Prime Minister to advise Her Majesty the Queen to prorogue Parliament is not justiciable in Her Majesty’s courts.”

For three days last week, the court heard arguments from the two sides. Former prime minister John Major has accused Johnson of misleading the Queen, and argued that the true intent of seeking prorogation was to shut down debate in parliament, as the Court of Session found. The government’s counter-argument was that prorogation is a political tool given by the legislature to the executive branch. If Parliament does not like prorogation or how it is used, it has the power to change the law. It is not for the Court to opine about the motivations, argued the government’s lawyer, Richard Keen.

Britons voted in a 2016 referendum to leave the EU. After failed negotiations for a deal on trade and deadline extension the deadline currently stands at October 31, 2019. Johnson has repeatedly stated that Britain must leave by that date with or without a deal. On September 13 — two days after the Court of Session ruling — he said he remained “cautiously optimistic” a deal would be reached.

Monday, September 7, 2015

The US economy added 173,000 jobs in August, the Bureau of Labor Statistics reported on Friday. The unemployment rate fell from 5.3 to 5.1 percent, the lowest since April 2008.

Although August job gains were lower than most economists forecast, job growth numbers for June and July were revised upwards by a combined 44,000. Average job gains over the past three months stand at 221,000, compared to March-May’s 189,000 monthly average. Over the past twelve months, job growth has averaged 247,000 per month.

Average hourly earnings rose 0.3 percent, or 8 cents, marking the largest increase in earnings in seven months. Hourly earnings had risen by 6 cents in July. Wages have risen by 2.2 percent over the past year.

Job growth in August was primarily concentrated in the health care and social assistance, financial activities, and professional and business services sectors. Those three areas of the economy added a combined 108,000 jobs. Food service and drinking places employment increased by 26,000 over the month, and other economic sectors saw employment hold steady. Manufacturing, on the other hand, saw employment decline by 17,000 in August. A stronger dollar and worldwide economic weakness make US exports less desirable, leading to a flattening in manufacturing employment so far this year after steadily rising in the early years of the US economic recovery.

The solid overall job gains led analysts to slightly raise expectations for a decision by the Federal Reserve to raise interest rates this month. Investors raised the likelihood of a September rate increase from 26 percent before the jobs report to 30 percent, and stocks dropped by over one percent on Friday. “The payrolls data is certainly good enough to allow for a Fed rate hike in September,” said Deutsche Bank’s head of currency strategy, Alan Ruskin. “The big question is still whether financial market volatility will scupper the plans.”

“This is the first time the market has looked at a Fed meeting and really has no idea what the Fed is going to do,” said Mark Kepner, a New Jersey equity trader with Themis Trading. “Right now you’re looking at the overall uncertainty and that’s what’s hanging on the market. I don’t think this number in and of itself changes how somebody’s going to vote.”

Sunday, November 23, 2008

A Pembroke Pines, Florida teenager killed himself Wednesday, November 19, while broadcasting on the live video site Justin.tv. After making suicide threats and being encouraged by Justin.tv viewers and Bodybuilding.com forum members, Abraham K. Biggs, 19, committed suicide by taking an overdose of opiates and benzodiazepine, which had been prescribed for his bipolar disorder.

Biggs first began blogging about his planned suicide 12 hours before the actual event. He died after taking pills and lying on the bed in front of the webcam. After the broadcast, viewers who apparently thought it was a hoax posted messages such as “OMG”, “LOL”, and “hahahah”.

Hours later, after being alerted by viewers who had noticed that Biggs had stopped breathing, law enforcement and paramedics arrived, discovered his body, and covered the camera. The Broward County Medical Examiner’s Office has reportedly confirmed Biggs’ death.

According to Montana Miller of the Bowling Green State University, the circumstances of this case were not shocking: “If it’s not recorded or documented, then it doesn’t even seem worthwhile. For today’s generation it might seem, ‘What’s the point of doing it if everyone isn’t going to see it?'”

Biggs’ sister Rosalind was angry that neither the website nor its viewers reacted soon enough to save him. “They got hits, they got viewers, nothing happened for hours,” she said. She described him as “very happy” and “friendly and outgoing.” “On a normal day, you couldn’t really tell that he got as low as he did.” However, he did have relationship problems with his girlfriend, according to a friend.

Mental health professionals have warned about the possibility that other mentally troubled people would copy his actions. According to Dr. David Shaffer of Columbia University, “Any video showing it as heroic or romantic or glamorous could reduce the anxiety people might feel about suicide. It becomes a respectable behavior and lowers the threshold of suicide.” He and other psychiatrists recommend that potentially suicidal teens talk to others and “tell what’s going on.”

Sunday, November 19, 2006

Deputy to the Iraq Health Minister, Ammar al-Saffar, who lives with his sister in Baghdad’s Sunni neighbourhood of Adhamiya, was kidnapped today.

It is reported that six uniformed men and others wearing suits, arrived at Mr Saffer’s home in police cars and pickup trucks and took him off.

As one of the deputies to the Health Minister, Mr Saffer called earlier this year for as much as $8 Billion to restore Iraq’s health services.

On August 9, 2006, Mr Saffar discussed the health situation in Iraq with the BBC. He said that the insurgents were killing doctors and trying to create a brain drain. 100 doctors had been killed “because they were trying to help people and because they were Shia”. He said that there are about 18,000 doctors in Iraq but many have left, while others practice at home rather than at hospitals where they could be better protected. Under Saddam they were not permitted to leave, now there is no restriction. But now there are cash incentives: under Saddam they earned $2-3 a month, now they can earn up to $500 a month. On security, he said that the people blamed the US for the violence because, although they were responsible for security, they left the borders poorly guarded.

Mr Saffer survived an assassination attempt in June, 2004 when he was fired upon as he left his home. He was uninjured.

Friday, September 15, 2006

Jesse Sullivan has two cybernetic arms, after electrical burns suffered while working as an electrical utility lineman resulted in amputation of both his arms at the shoulder. Claudia Mitchell has a similar cybernetic left arm, after a motorcycle accident resulted in amputation. Sullivan and Mitchell shook hands with these thought-controlled prosthetic arms at an event staged Thursday in Washington, D.C. by the Defense Advanced Research Projects Agency (DARPA) and Center for Artificial Limbs at the Rehabilitation Institute of Chicago.

Unlike traditional prosthetic limbs, these are actuated through muscle reinnervation; nerves are grafted onto specific muscles, controlling their contraction, which are then detected by electrode sensors and control the prosthetic limb. “Basically it is connecting the dots. Finding the nerves. We have to free the nerves and see how far they reach,” says Dr. Todd Kuiken, developer of the prostheses and director of neuroengineering at the Rehabilitation Institute. By this chain of communication the prostheses utilize thought-controlled biomechanics. According to Sullivan, “When I use the new prosthesis I just do things. I don’t have to think about it … I do all the yard work. I take out the garbage.”

DARPA, as an agency of the United States Department of Defense, seeks to eventually provide such prostheses for soldiers losing their organic limbs in combat. “We’re excited about collaborating with the military,” said Kuiken. 411 U.S. troops in Iraq and 37 in Afghanistan have had wounds that cost them at least one limb according to the Army Medical Command.